The significance of cytomegalovirus infection over the clinical course of adult T-cell leukemia/lymphoma

被引：10

作者：

Fujiwara, H

Eizuru, Y

Matsumoto, T

Kukita, T

Imaizumi, R

Kawada, H

Ohtsubo, H

Matsushita, K

Arima, N

Tei, C

机构：

[1] Kagoshima Univ, Fac Med, Div Persistent & Oncogen Viruses, Ctr Chron Viral Dis, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Fac Med, Dept Internal Med 1, Ctr Chron Viral Dis, Kagoshima 8908520, Japan

[3] Jiaikai Imamura Hosp, Div Hematol, Kagoshima 8920824, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2001年 / 45卷 / 01期

关键词：

CMV; antigenemia; ATL;

D O I：

10.1111/j.1348-0421.2001.tb01265.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The significance of cytomegalovirus (CMV) infections developed over the clinical course of adult T-cell leukemia/lymphoma (ATLL) were evaluated in relation to the patient survival rate, ATL activity and immunocompetent cells. ATLL patients with CMV infections on admission exhibited a poor survival rate, while patients with CMV infections at any time after admission survived longer than those not infected with this virus. ATLL patients who exhibited a numbers of CMV infection on admission showed higher ATL activity and had lower numbers of CDS-positive and CD56-positive cells than those who developed CMV infections at any time after admission. Therefore, it appears likely that patients with CMV infections on admission were in an immunosuppressive state due to aggressive ATL activity.

引用

页码：97 / 100

页数：4

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