Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase

被引：50

作者：

Kim, DK ^{[1
]}

Lee, K

机构：

[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea

[2] Woosuk Univ, Dept Chem, Samrye 565701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2003年 / 26卷 / 09期

关键词：

celtis chinensis; acetylcholinesterase; trans-N-p-coumaroyl tyramine;

D O I：

10.1007/BF02976684

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 mug/mL (122 muM).

引用

页码：735 / 738

页数：4

共 18 条

[1] On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis [J].