Synthesis of clustered D-GalNAc(Tn) and D-Gal beta(1->3)GalNAc(T) antigenic motifs using a pentaerythritol scaffold

被引：35

作者：

Hanessian, S

Qiu, DX

Prabhanjan, H

Reddy, GV

Lou, BL

机构：

[1] Department of Chemistry, Université de Montréal, Montréal, Que. H3C 3J7, Succ. Centre Ville

来源：

CANADIAN JOURNAL OF CHEMISTRY | 1996年 / 74卷 / 09期

关键词：

glycoside synthesis; 2-thiopyridyl carbonate; glycosyl donors and glycopeptide motifs;

D O I：

10.1139/v96-192

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The tris(aminoethyl) and triamino derivatives of pentaerythritol have been used as scaffolds or templates for the attachment of immunologically relevant carbohydrates such as D-Gal beta(1 --> 3)GalNAc (T) and GalNAc (Tn), through amide linkages with the respective alpha-glycolyl and alpha-N-acetyl-L-serinyl glycosides. These clustered glycosidic motifs are intended as haptens for use in the preparation of tumor specific carbohydrate antigens and vaccines.

引用

页码：1738 / 1747

页数：10

共 65 条

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ADACHI T, 1977, SYNTHESIS-STUTTGART, P45

[2] MALIGNANT-CELL GLYCOPROTEINS AND GLYCOLIPIDS [J].