Asymmetric induction using atropisomers: Diastereoselective additions to 2-acyl-1-naphthamides

被引：47

作者：

Clayden, J ^{[1
]}

Westlund, N ^{[1
]}

Wilson, FX ^{[1
]}

机构：

[1] ROCHE PROD LTD,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/0040-4039(96)01129-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The amide group of 2-acyl-N,N-dialkyl-1-naphthamides, twisted perpendicular to the naphthyl ring, controls the stereoselectivity of attack of nucleophiles on the 2-substituent. Selectivities of >140:1 may be achieved with bulky nucleophiles, which attack anti to the N,N-dialkyl group. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5577 / 5580

页数：4

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