TEL/AML1 and immunoreceptor gene rearrangements - which comes first?

被引：5

作者：

Zuna, J

Krejci, O

Madzo, J

Fronkova, E

Sramkova, L

Hrusak, O

Kalina, T

Vaskova, M

Stary, J

Trka, J

机构：

[1] Charles Univ, Sch Med 2, CLIP, Childhood Leukaemia Invest Prague, Prague, Czech Republic

[2] Charles Univ, Sch Med 2, Dept Paediat Haematol & Oncol, Prague 15006 5, Czech Republic

[3] Charles Univ, Sch Med 2, Dept Immunol, Prague, Czech Republic

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 06期

关键词：

acute lymphoblastic leukaemia; TEL/AML1; immunoglobulin; T-cell receptor; rearrangenlent relapse;

D O I：

10.1016/j.leukres.2004.11.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangernents between diagnosis and relapse suggest that in most cases the TEL/AML 1 fusion is formed during immunoreceptor gene rearrangement process. (c) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：633 / 639

页数：7

相关论文

共 16 条

[1] Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia [J].

Ford, AM ;

Bennett, CA ;

Price, CM ;

Bruin, MCA ;

Van Wering, ER ;

Greaves, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4584-4588

[2] Origins of "late" relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes [J].

Ford, AM ;

Fasching, K ;

Panzer-Grümayer, ER ;

Koenig, M ;

Haas, OA ;

Greaves, MF .

BLOOD, 2001, 98 (03) :558-564

[3] High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias [J].

Hübner, S ;

Cazzaniga, G ;

Flohr, T ;

van der Velden, VHJ ;

Konrad, M ;

Pötschger, U ;

Basso, G ;

Schrappe, M ;

van Dongen, JJM ;

Bartram, CR ;

Biondi, A ;

Panzer-Grümayer, ER .

LEUKEMIA, 2004, 18 (01) :84-91

[4] Cutting edge:: TCR δ gene is frequently rearranged in adult B lymphocytes [J].

Krejci, O ;

Prouzova, Z ;

Horvath, O ;

Trka, J ;

Hrusak, O .

JOURNAL OF IMMUNOLOGY, 2003, 171 (02) :524-527

[5] Chromosome translocations and covert leukemic clones are generated during normal fetal development [J].

Mori, H ;

Colman, SM ;

Xiao, ZJ ;

Ford, AM ;

Healy, LE ;

Donaldson, C ;

Hows, JM ;

Navarrete, C ;

Greaves, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8242-8247

[6] Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development [J].

Peham, M ;

Konrad, M ;

Harbott, J ;

König, M ;

Haas, OA ;

Panzer-Grümayer, ER .

GENES CHROMOSOMES & CANCER, 2004, 39 (02) :156-160

[7] Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets -: Report of the BIOMED-1 CONCERTED ACTION:: Investigation of minimal residual disease in acute leukemia [J].

Pongers-Willemse, MJ ;

Seriu, T ;

Stolz, F ;

d'Aniello, E ;

Gameiro, P ;

Pisa, P ;

Gonzalez, M ;

Bartram, CR ;

Panzer-Grümayer, ER ;

Biondi, A ;

San Miguel, JF ;

van Dongen, JJM .

LEUKEMIA, 1999, 13 (01) :110-118

[8] Precursor-B-ALL with DH-JH gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14 [J].

Szczepanski, T ;

Willemse, MJ ;

van Wering, ER ;

van Weerden, JF ;

Kamps, WA ;

van Dongen, JJM .

LEUKEMIA, 2001, 15 (09) :1415-1423

[9] High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia [J].

Taub, JW ;

Konrad, MA ;

Ge, YB ;

Naber, JM ;

Scott, JS ;

Matherly, LH ;

Ravindranath, Y .

BLOOD, 2002, 99 (08) :2992-2996

[10] Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL [J].

van der Burg, M ;

Barendregt, BH ;

Szczepañski, T ;

van Wering, ER ;

Langerak, AW ;

van Dongen, JJM .

LEUKEMIA, 2002, 16 (08) :1448-1453