Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: Identification and optimisation of substituted 4,6-bis anilino pyrimidines

被引：80

作者：

Beattie, JF ^{[1
]}

Breault, GA ^{[1
]}

Ellston, RPA ^{[1
]}

Green, S ^{[1
]}

Jewsbury, PJ ^{[1
]}

Midgley, CJ ^{[1
]}

Naven, RT ^{[1
]}

Minshull, CA ^{[1
]}

Pauptit, RA ^{[1
]}

Tucker, JA ^{[1
]}

Pease, JE ^{[1
]}

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(03)00202-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase. CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2955 / 2960

页数：6

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