Blockade of IL-6 Secretion Pathway by the Sesquiterpenoid Atractylenolide III

被引：59

作者：

Kang, Tae-Hee ^{[1
]}

Han, Na-Ra ^{[1
]}

Kim, Hyung-Min ^{[1
]}

Jeong, Hyun-Ja ^{[2
]}

机构：

[1] Kyung Hee Univ, Coll Oriental Med, Dept Pharmacol, Seoul 130701, South Korea

[2] Hoseo Univ, Biochip Res Ctr, Asan 336795, Chungnam, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 02期

关键词：

CASPASE RECRUITMENT DOMAIN; RECEPTOR-INTERACTING PROTEIN-2; MAST-CELLS; ESSENTIAL OIL; ACTIVATION; PATHOGENESIS; INFLAMMATION; COMPONENTS; RESPONSES; INNATE;

D O I：

10.1021/np100686a

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Atractylenolide III (1) is the major bioactive component of Atractylodes lancea. The aim of this study was to analyze the effect on the regulation of interleukin (IL)-6 secretion pathway caused by 1. This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. In addition, 1 inhibited histamine release in stimulated HMC-1 cells. In stimulated HMC-1 cells, 1 suppressed activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-kappa B. In addition, 1 suppressed the activation of caspase-1 and the expression of receptor interacting protein-2. These results provide new insights that atractylenolide III (1) may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

引用

页码：223 / 227

页数：5

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