Phylogenetic analysis of GB virus C: Comparison of isolates from Africa, North America, and Taiwan

被引：52

作者：

Kao, JH

Chen, PJ

Hsiang, SC

Chen, W

Chen, DS

机构：

[1] NATL TAIWAN UNIV HOSP, HEPATITIS RES CTR, TAIPEI 100, TAIWAN

[2] NATL TAIWAN UNIV HOSP, DEPT INTERNAL MED, GRAD INST CLIN MED, TAIPEI 100, TAIWAN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1996年 / 174卷 / 02期

关键词：

D O I：

10.1093/infdis/174.2.410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A group of flavi-like GB viruses (GBV-A, -B, and -C) has been discovered and partially characterized. Only GBV-C is found in humans. Nucleotide sequences of the putative helicase gene of the GBV-C genome were determined in 21 Taiwanese patients and compared with isolates from Africa and North America by phylogenetic analysis. The average similarities of Taiwanese isolates to those from West Africa, East Africa, Canada, and United States were 83%, 85%, 78%, and 82%, respectively. Phylogenetic analysis of the NS3 region showed that 81% of the Taiwanese isolates were more closely related to the East African isolate. GBV-C isolates from Taiwan could be classified into at least 3 groups. These data suggest that GBV-C isolates cloned from different geographic areas have genetic heterogeneity.

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收藏

页码：410 / 413

页数：4

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