Design and baseline characteristics of a trial on health effects of soy protein with isoflavones in postmenopausal women

被引：11

作者：

Kok, L ^{[1
]}

Kreijkamp-Kaspers, S ^{[1
]}

Grobbee, DE ^{[1
]}

van der Schouw, YT ^{[1
]}

机构：

[1] Univ Utrecht, Ctr Med, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands

来源：

MATURITAS | 2004年 / 47卷 / 01期

关键词：

soy protein; isoflavones; health effects; postmenopausal women;

D O I：

10.1016/S0378-5122(03)00243-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

This study is a double-blind, randomized, placebo-controlled trial to assess the effects of high amounts of phytoestrogens on bone mineral density, cardiovascular diseases, cognitive function, performance in activities of daily life and well being. Participants were healthy postmenopausal women, aged 60-75 years. Between March and September 2000, 202 women were recruited, and, after completion of the baseline measurements, randomized to either soy protein, containing 99 mg naturally occurring isoflavones or placebo (milk protein) daily for 1 year. Analysis of the endpoints will be based on the difference between baseline measurements and measurements at the end of the intervention period with group allocation as independent variable. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：21 / 29

页数：9

共 51 条

[1] Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis [J].

Adams, MR ;

Golden, DL ;

Wagner, JD ;

Williams, JK .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :217-221

[2] The effect of dietary soy supplementation on hot flushes [J].

Albertazzi, P ;

Pansini, F ;

Bonaccorsi, G ;

Zanotti, L ;

Forini, E ;

De Aloysio, D .

OBSTETRICS AND GYNECOLOGY, 1998, 91 (01) :6-11

[3] METAANALYSIS OF THE EFFECTS OF SOY PROTEIN-INTAKE ON SERUM-LIPIDS [J].

ANDERSON, JW ;

JOHNSTONE, BM ;

COOKNEWELL, ME .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (05) :276-282

[4]

[Anonymous], J GERONTOL

[5] Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys [J].

Anthony, MS ;

Clarkson, TB ;

Hughes, CL ;

Morgan, TM ;

Burke, GL .

JOURNAL OF NUTRITION, 1996, 126 (01) :43-50

[6] Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys [J].

Anthony, MS ;

Clarkson, TB ;

Bullock, BC ;

Wagner, JD .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) :2524-2531

[7]

Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0

[8] VALIDATING THE SF-36 HEALTH SURVEY QUESTIONNAIRE - NEW OUTCOME MEASURE FOR PRIMARY CARE [J].

BRAZIER, JE ;

HARPER, R ;

JONES, NMB ;

OCATHAIN, A ;

THOMAS, KJ ;

USHERWOOD, T ;

WESTLAKE, L .

BMJ-BRITISH MEDICAL JOURNAL, 1992, 305 (6846) :160-164

[9] Effects of hormonal therapies and dietary soy phytoestrogens on vaginal cytology in surgically postmenopausal macaques [J].

Cline, JM ;

Paschold, JC ;

Anthony, MS ;

Obasanjo, IO ;

Adams, MR .

FERTILITY AND STERILITY, 1996, 65 (05) :1031-1035

[10] Population-based case-control study of soyfood intake and breast cancer risk in Shanghai [J].

Dai, Q ;

Shu, XO ;

Jin, F ;

Potter, JD ;

Kushi, LH ;

Teas, J ;

Gao, YT ;

Zheng, W .

BRITISH JOURNAL OF CANCER, 2001, 85 (03) :372-378

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