Molecular mechanisms of liver metastasis

被引：25

作者：

Kawada, Kenji ^{[1
]}

Hasegawa, Suguru ^{[1
]}

Murakami, Teppei ^{[1
]}

Itatani, Yoshiro ^{[1
,2
]}

Hosogi, Hisahiro ^{[1
]}

Sonoshita, Masahiro ^{[2
]}

Kitamura, Takanori ^{[2
]}

Fujishita, Teruaki ^{[2
]}

Iwamoto, Masayoshi ^{[1
]}

Matsumoto, Takuya ^{[1
]}

Matsusue, Ryo ^{[1
]}

Hida, Koya ^{[1
]}

Akiyama, Gaku ^{[1
]}

Okoshi, Kae ^{[1
]}

Yamada, Masahiro ^{[1
]}

Kawamura, Junichiro ^{[1
]}

Taketo, Makoto Mark ^{[2
]}

Sakai, Yoshiharu ^{[1
]}

机构：

[1] Kyoto Univ, Dept Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

[2] Kyoto Univ, Dept Pharmacol, Grad Sch Med, Kyoto 6068507, Japan

来源：

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2011年 / 16卷 / 05期

关键词：

Liver metastasis; Colorectal cancer; Chemokine; COLON-CARCINOMA CELLS; BREAST-CANCER METASTASIS; CHEMOKINE RECEPTOR CXCR4; IMMATURE MYELOID CELLS; C-X-C; COLORECTAL-CANCER; TUMOR-GROWTH; PROMOTES METASTASIS; PIVOTAL ROLE; LYMPH-NODES;

D O I：

10.1007/s10147-011-0307-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrow-derived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.

引用

页码：464 / 472

页数：9

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