Aromatase and interleukin-10 genetic variants interactively modulate Alzheimer's disease risk

被引：28

作者：

Combarros, O. ^{[1
,2
]}

Sanchez-Juan, P. ^{[3
]}

Riancho, J. A. ^{[4
]}

Mateo, I. ^{[1
,2
]}

Rodriguez-Rodriguez, E. ^{[1
,2
]}

Infante, J. ^{[1
,2
]}

Garcia-Gorostiaga, I. ^{[1
,2
]}

Vazquez-Higuera, J. L. ^{[1
,2
]}

Berciano, J. ^{[1
,2
]}

机构：

[1] Univ Cantabria, Marques Valdecilla Univ Hosp, Neurol Serv, Santander 39008, Spain

[2] Univ Cantabria, Marques Valdecilla Univ Hosp, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Santander 39008, Spain

[3] Fdn Marques de Valdecilla IFIMAV, Inst Format & Res, Santander, Spain

[4] Univ Cantabria, Marques Valdecilla Univ Hosp, Dept Internal Med, E-39005 Santander, Spain

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 06期

关键词：

Alzheimer's disease; aromatase; interleukin-10; polymorphism; epistasis;

D O I：

10.1007/s00702-008-0028-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). Estrogen could protect the brain from neurodegeneration by augmenting the secretion of the anti-inflammatory interleukin (IL)-10 from microglial cells. In a case-control study in 231 AD patients and 194 healthy controls, we examined whether the combined effects between the genes coding for aromatase (a critical enzyme in the peripheral synthesis of estrogens) and IL-10 might be responsible for susceptibility to AD. Subjects carrying both the aromatase (5'-UTR) GG and the IL-10 (-1082) GG genotypes had a six times lower risk of developing AD than subjects without these risk genotypes (OR = 0.17, 95% CI = 0.04-0.77, P = 0.02).

引用

页码：863 / 867

页数：5

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