Serum Levels of Lipids, Lipoproteins and Paraoxonase Activity in Pre-eclampsia

被引：38

作者：

Demir, B. ^{[1
]}

Demir, S. ^{[1
]}

Atamer, Y. ^{[2
]}

Guven, S. ^{[5
]}

Atamer, A. ^{[6
]}

Kocyigit, Y. ^{[3
]}

Hekimoglu, A. ^{[4
]}

Toprak, G. ^{[2
]}

机构：

[1] Ergani State Hosp, Dept Obstet & Gynaecol, Diyarbakir, Turkey

[2] Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey

[3] Dicle Univ, Fac Med, Dept Physiol, Diyarbakir, Turkey

[4] Dicle Univ, Fac Med, Dept Pharmacol, Diyarbakir, Turkey

[5] Karadeniz Tech Univ, Dept Obstet & Gynaecol, Sch Med, Trabzon, Turkey

[6] Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol & Internal Med, Istanbul, Turkey

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 04期

关键词：

PRE-ECLAMPSIA; LIPIDS; LIPOPROTEINS; PARAOXONASE ACTIVITY; PREGNANCY-INDUCED HYPERTENSION; LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL DYSFUNCTION; OXIDATIVE MODIFICATION; NITRIC-OXIDE; PEROXIDATION; PLASMA; MALONDIALDEHYDE; SUSCEPTIBILITY; ANTIBODIES;

D O I：

10.1177/147323001103900430

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Serum paraoxonase 1 (PON1) activity and the oxidation of lipoproteins were investigated in 35 women with preeclampsia and in 35 healthy control women with normal pregnancies. Blood pressure, body mass index (BMI), serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (a) (Lp[a]), and PON1 activity were assessed. There were no significant between-group differences in subject age, gestational age at diagnosis of preeclampsia, BMI, serum total cholesterol, triglycerides, LDL and ApoB levels. Mean systolic and diastolic blood pressures and serum Lp(a) were significantly higher in subjects with pre-eclampsia than in controls. Mean serum HDL, ApoA1 and PON1 activity were significantly lower in subjects with pre-eclampsia compared with controls. In conclusion, lipids and oxidized lipoproteins may play important roles in the pathogenesis of preeclampsia.

引用

页码：1427 / 1431

页数：5

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