Three-dimensional (3D) printed scaffold and material selection for bone repair

被引:657
作者
Zhang, Lei [1 ]
Yang, Guojing [1 ]
Johnson, Blake N. [2 ]
Jia, Xiaofeng [3 ,4 ,5 ,6 ,7 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 3, Dept Orthopaed, Wenzhou 325200, Zhejiang, Peoples R China
[2] Virginia Tech, Dept Ind & Syst Engn, Blacksburg, VA 24061 USA
[3] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA
[4] Univ Maryland, Sch Med, Dept Orthoped, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA
[6] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA
[7] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA
关键词
3D printing; Bone tissue engineering; Bone defect; Porous scaffold; Biomaterials; BETA-TRICALCIUM PHOSPHATE; MESENCHYMAL STEM-CELLS; BIOACTIVE GLASS SCAFFOLDS; PROMOTES CHONDROGENIC DIFFERENTIATION; POLY(PROPYLENE FUMARATE) SCAFFOLDS; POROUS HYDROXYAPATITE SCAFFOLDS; EPSILON-CAPROLACTONE SCAFFOLDS; POLY(LACTIC ACID) SCAFFOLDS; POLY-LACTIC-ACID; MECHANICAL-PROPERTIES;
D O I
10.1016/j.actbio.2018.11.039
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
Critical-sized bone defect repair remains a substantial challenge in clinical settings and requires bone grafts or bone substitute materials. However, existing biomaterials often do not meet the clinical requirements of structural support, osteoinductive property, and controllable biodegradability. To treat large-scale bone defects, the development of three-dimensional (3D) porous scaffolds has received considerable focus within bone engineering. A variety of biomaterials and manufacturing methods, including 3D printing, have emerged to fabricate patient-specific bioactive scaffolds that possess controlled micro-architectures for bridging bone defects in complex configurations. During the last decade, with the development of the 3D printing industry, a large number of tissue-engineered scaffolds have been created for preclinical and clinical applications using novel materials and innovative technologies. Thus, this review provides a brief overview of current progress in existing biomaterials and tissue engineering scaffolds prepared by 3D printing technologies, with an emphasis on the material selection, scaffold design optimization, and their preclinical and clinical applications in the repair of critical-sized bone defects. Furthermore, it will elaborate on the current limitations and potential future prospects of 3D printing technology. Statement of Significance 3D printing has emerged as a critical fabrication process for bone engineering due to its ability to control bulk geometry and internal structure of tissue scaffolds. The advancement of bioprinting methods and compatible ink materials for bone engineering have been a major focus to develop optimal 3D scaffolds for bone defect repair. Achieving a successful balance of cellular function, cellular viability, and mechanical integrity under load-bearing conditions is critical. Hybridization of natural and synthetic polymerbased materials is a promising approach to create novel tissue engineered scaffolds that combines the advantages of both materials and meets various requirements, including biological activity, mechanical strength, easy fabrication and controllable degradation. 3D printing is linked to the future of bone grafts to create on-demand patient-specific scaffolds. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:16 / 33
页数:18
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