Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage

被引:215
作者
Lyon, Delina Y. [1 ]
Brunet, Lena [1 ]
Hinkal, George W. [2 ]
Wiesner, Mark R. [3 ]
Alvarez, Pedro J. J. [1 ]
机构
[1] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA
[2] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[3] Duke Univ, Dept Civil & Environm Engn, Durham, NC 27708 USA
关键词
D O I
10.1021/nl0726398
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The cytotoxic and antibacterial properties of nC(60), a buckminsterfullerene water suspension, have been attributed to photocatalytically generated reactive oxygen species (ROS). However, in this work, neither ROS production nor ROS-mediated damage is found in nC(60)-exposed bacteria. Furthermore, the colorimetric methods used to evaluate ROS production and damage are confounded by interactions between nC(60) and the reagents, yielding false positives. Instead, we propose that nC(60) exerts ROS-independent oxidative stress, thus reconciling conflicting results in the literature.
引用
收藏
页码:1539 / 1543
页数:5
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