Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents.

被引：184

作者：

Antolini, M ^{[1
]}

Bozzoli, A ^{[1
]}

Ghiron, C ^{[1
]}

Kennedy, G ^{[1
]}

Rossi, T ^{[1
]}

Ursini, A ^{[1
]}

机构：

[1] GlaxoWellcome SPA, Med Res Ctr, I-37135 Verona, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00112-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant Staphylococcus aureus (MRSA). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1023 / 1028

页数：6

共 14 条

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