Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin

被引：41

作者：

Langlois, N ^{[1
]}

Rojas-Rousseau, A

Gaspard, C

Werner, GH

Darro, F

Kiss, R

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Free Univ Brussels, Fac Med, Histol Lab, B-1070 Brussels, Belgium

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 22期

关键词：

D O I：

10.1021/jm010937q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo [2, 1-c] [1,4] benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.

引用

页码：3754 / 3757

页数：4

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