Human leukocyte antigen class I and II Alleles and response to interferon-α treatment, in Taiwanese patients with chronic hepatitis C virus infection

被引：29

作者：

Yu, ML ^{[1
]}

Dai, CY ^{[1
]}

Chen, SC ^{[1
]}

Chiu, CC ^{[1
]}

Lee, LP ^{[1
]}

Lin, ZY ^{[1
]}

Hsieh, MY ^{[1
]}

Wang, LY ^{[1
]}

Chuang, WL ^{[1
]}

Chang, WY ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Internal Med, Hepatobiliary Div, Kaohsiung 807, Taiwan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 188卷 / 01期

关键词：

D O I：

10.1086/375554

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate the influence of immunogenetics on response to interferon (IFN)-alpha treatment, human leukocyte antigen alleles were characterized in 100 unrelated Taiwanese patients with chronic hepatitis C virus (HCV) infection. A11, B51, Cw15, and DRB1*15 were positively correlated with sustained response, whereas A24 was inversely associated with response to IFN-alpha, after adjustment for cirrhosis, pretreatment virus load, and viral genotype. Homozygote-genotype analysis showed that A24 and DQB1*05 probably had gene-dosage effect on sustained response. DRB1*15 was in strong linkage disequilibrium with DQB1*05 and DQB1*06, but only haplotype DRB1*15-DQB1*05 was associated with response to IFN-alpha. Haplotype A11-DRB1*15 was strongly associated with sustained response. This suggests a role for a complex host-immunogenetics interplay in the response to IFN-alpha, in patients with chronic HCV infection.

引用

页码：62 / 65

页数：4

共 15 条

[1] Interferon-α therapy in HCV hepatitis:: HLA phenotype and cirrhosis are independent predictors of clinical outcome [J].

Almarri, A ;

El Dwick, N ;

Al Kabi, S ;

Sleem, K ;

Rashed, A ;

Ritter, MA ;

Batchelor, JR .

HUMAN IMMUNOLOGY, 1998, 59 (04) :239-242

[2] Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection [J].

Alric, L ;

Izopet, J ;

Fort, M ;

Vinel, JP ;

Fontenelle, P ;

Orfila, C ;

Payen, JL ;

Sandres, K ;

Desmorat, H ;

Charlet, JP ;

Duffaut, M ;

Abbal, M .

HUMAN IMMUNOLOGY, 1999, 60 (06) :516-523

[3] Genes of major histocompatibility complex class II influence chronic C hepatitis treatment with interferon in hemodialysis patients [J].

Dinçer, D ;

Besisik, F ;

Oguz, F ;

Sever, MS ;

Kaymakoglu, S ;

Çakaloglu, Y ;

Demir, K ;

Türkoglu, S ;

Çarin, M ;

Okten, A .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2001, 24 (04) :212-214

[4]

Ikeda-Moore Y, 1997, J IMMUNOL, V159, P6242

[5] The effect of HLA alleles on response to interferon therapy in patients with chronic hepatitis C [J].

Kikuchi, I ;

Ueda, A ;

Mihara, K ;

Miyanaga, O ;

Machidori, H ;

Ishikawa, E ;

Tamura, K .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1998, 10 (10) :859-863

[6] Medical progress: Hepatitis C virus infection. [J].

Lauer, GM ;

Walker, BD .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (01) :41-52

[7]

Lechmann M, 1999, EUR J CLIN INVEST, V29, P337

[8]

Missale G, 1997, HEPATOLOGY, V26, P792, DOI 10.1053/jhep.1997.v26.pm0009303515

[9] Possible association between HLA antigens and the response to interferon in Japanese patients with chronic hepatitis C [J].

Miyaguchi, S ;

Saito, H ;

Ebinuma, H ;

Morizane, T ;

Ishii, H .

TISSUE ANTIGENS, 1997, 49 (06) :605-611

[10] CHARACTERIZATION OF THE GENOMIC SEQUENCE OF TYPE-V (OR 3A) HEPATITIS-C VIRUS ISOLATES AND PCR PRIMERS FOR SPECIFIC DETECTION [J].

OKAMOTO, H ;

TOKITA, H ;

SAKAMOTO, M ;

HORIKITA, M ;

KOJIMA, M ;

IIZUKA, H ;

MISHIRO, S .

JOURNAL OF GENERAL VIROLOGY, 1993, 74 :2385-2390

← 1 2 →