Human innate B cells: a link between host defense and autoimmunity?

被引：57

作者：

Milner, ECB ^{[1
]}

Anolik, J ^{[1
]}

Cappione, A ^{[1
]}

Sanz, I ^{[1
]}

机构：

[1] Univ Rochester, Sch Med, Dept Med, Clin Immunol & Rheumatol Unit, Rochester, NY 14642 USA

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 2005年 / 26卷 / 04期

关键词：

B cells/B lymphocytes; autoimmunity; innate immunity; immunoregulation; human;

D O I：

10.1007/s00281-004-0188-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells play a variety of immunoregulatory roles through their anti gen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.

引用

页码：433 / 452

页数：20

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