Spontaneous regeneration of nigrostriatal dopaminergic neurons in MPTP-treated C57BL/6 mice

被引：91

作者：

Mitsumoto, Y ^{[1
]}

Watanabe, A

Mori, A

Koga, N

机构：

[1] Otsuka Pharmaceut Co Ltd, Tokushima New Drug Res Inst, Tokushima 7710192, Japan

[2] Otsuka Pharmaceut Co Ltd, Inst Exploratory Drug Res, Osaka 5400021, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 248卷 / 03期

关键词：

MPTP; nigrostriatal neurons; neurodegeneration; regeneration; Parkinson's disease;

D O I：

10.1006/bbrc.1998.8986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spontaneous recovery of nigrostriatal dopaminergic neurons was quantitatively analyzed with tyrosine hydroxylase (TH)-immunocytochemistry in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)treated C57BL/6 young mice. A substantial reduction of striatal dopamine (DA) level was observed until 24 days following MPTP treatment. The TH-immunoreactive (IR) fibers and number of TH-positive cell bodies were also markedly reduced at 3 days after the toxin treatment. Thereafter, TH-IR fiber densities showed to progressively recover through the examining period. The number of TH-positive cell bodies in substantia nigra pars compacta were not changed during the recovery period. These results indicate that MPTP-treated mice have a potential for spontaneous regenerative sprouting in nigrostriatal dopaminergic system. (C) 1998 Academic Press.

引用

页码：660 / 663

页数：4

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