The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

被引：190

作者：

Sanz-Moreno, Victoria ^{[1
]}

Marshall, Christopher J. ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr Cell & Mol Biol, London SW3 6JB, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 05期

关键词：

FIBRILLAR COLLAGEN; MELANOMA-CELLS; 3D MATRICES; INVASION; MOTILITY; MODES; TRANSITION; ACTIVATION; SHAPE; RAC;

D O I：

10.1016/j.ceb.2010.08.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called 'amoeboid' modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.

引用

页码：690 / 696

页数：7

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