Effects of GR203040, an NK1 antagonist, on radiation- and cisplatin-induced tissue damage in the ferret

被引：11

作者：

Alfieri, AB

Gardner, CJ

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Syst Biol Res Unit, Stevenage SG1 2NY, Herts, England

[2] Cent Univ Venezuela, Sch Pharm, Dept Pharmacol, Caracas, Venezuela

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1998年 / 31卷 / 05期

关键词：

inflammation; NK1; receptor antagonist; cisplatin; X-irradiation; plasma protein extravasation; tissue damage; ferret;

D O I：

10.1016/S0306-3623(98)00111-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of GR203040, a tachykinin neurokinin(1) receptor antagonist, on tissue damage induced by X-irradiation (Rad) or cisplatin (Cisp) were investigated in ferrets. 2. GR203040 (0.3 mg/kg SC) reduced the Rad-induced plasma protein extravasation (PPE) in the duodenum and kidney by 25% in each tissue. 3. GR203040 (3 mg/kg SC, 5-min pretreatment and every 8 hr for 48 hr after Cisp) reduced the Cisp-induced PPE in the duodenum, jejunum and lung by 59, 52 and 60%, respectively. 4. Histological examination showed that GR203040 also ameliorated the Rad and Cisp-induced tissue damage. (C) 1998 Elsevier Science Inc.

引用

页码：741 / 746

页数：6

共 18 条

[1] The NK1 antagonist GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder [J].