Importins and exportins: how to get in and out of the nucleus

被引：202

作者：

Weis, K ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(98)01204-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Every minute, several million protein and RNA molecules must be transported between the cytoplasm and the nucleus of a eukaryotic cell. The characterization of mediators, receptors and accessory factors for different nuclear import and export pathways has provided a glimpse at the molecular machinery that is responsible for these trafficking events. It appears that both inbound and outbound traffic is mediated by a protein family of related transport factors that can be classified as importins and exportins.

引用

页码：185 / 189

页数：5

共 45 条

[1] Kap104p: A karyopherin involved in the nuclear transport of messenger RNA binding proteins [J].

Aitchison, JD ;

Blobel, G ;

Rout, MP .

SCIENCE, 1996, 274 (5287) :624-627

[2] Identification of a nuclear export receptor for tRNA [J].

Arts, GJ ;

Fornerod, M ;

Mattaj, IW .

CURRENT BIOLOGY, 1998, 8 (06) :305-314

[3] Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1 [J].

Boche, I ;

Fanning, E .

JOURNAL OF CELL BIOLOGY, 1997, 139 (02) :313-325

[4] IDENTIFICATION OF A NOVEL CELLULAR COFACTOR FOR THE REV/REX CLASS OF RETROVIRAL REGULATORY PROTEINS [J].

BOGERD, HP ;

FRIDELL, RA ;

MADORE, S ;

CULLEN, BR .

CELL, 1995, 82 (03) :485-494

[5] THE HIV-1 REV ACTIVATION DOMAIN IS A NUCLEAR EXPORT SIGNAL THAT ACCESSES AN EXPORT PATHWAY USED BY SPECIFIC CELLULAR RNAS [J].

FISCHER, U ;

HUBER, J ;

BOELENS, WC ;

MATTAJ, IW ;

LUHRMANN, R .

CELL, 1995, 82 (03) :475-483

[6] CRM1 is an export receptor for leucine-rich nuclear export signals [J].

Fornerod, M ;

Ohno, M ;

Yoshida, M ;

Mattaj, IW .

CELL, 1997, 90 (06) :1051-1060

[7] A HUMAN NUCLEOPORIN-LIKE PROTEIN THAT SPECIFICALLY INTERACTS WITH HIV REV [J].

FRITZ, CC ;

ZAPP, ML ;

GREEN, MR .

NATURE, 1995, 376 (6540) :530-533

[8] CRM1 is responsible for intracellular transport mediated by the nuclear export signal [J].

Fukuda, M ;

Asano, S ;

Nakamura, T ;

Adachi, M ;

Yoshida, M ;

Yanagida, M ;

Nishida, E .

NATURE, 1997, 390 (6657) :308-311

[9] Importin provides a link between nuclear protein and U snRNA export [J].

Gorlich, D ;

Kraft, R ;

Kostka, S ;

Vogel, F ;

Hartmann, E ;

Laskey, RA ;

Mattaj, IW ;

Izaurralde, E .

CELL, 1996, 87 (01) :21-32

[10] Protein kinesis - Nucleocytoplasmic transport [J].

Gorlich, D ;

Mattaj, IW .

SCIENCE, 1996, 271 (5255) :1513-1518

← 1 2 3 4 5 →