Fluoroquinolone prescribing in the United States: 1995 to 2002

被引:242
作者
Linder, JA
Huang, ES
Steinman, MA
Gonzales, R
Stafford, RS
机构
[1] Brigham & Womens Hosp, Div Gen Med, Boston, MA USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Chicago, Gen Internal Med Sect, Chicago, IL 60637 USA
[4] San Francisco VA Med Ctr, Div Geriatr, San Francisco, CA USA
[5] Univ Calif San Francisco, Div Gen Internal Med, San Francisco, CA 94143 USA
[6] Stanford Prevent Res Ctr, Program Prevent Outcomes & Practices, Stanford, CA USA
关键词
fluoroquinolones; antibiotics; physicians' practice patterns;
D O I
10.1016/j.amjmed.2004.09.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PURPOSE: To measure changes in the rate and type of fluoroquinolones prescribed in the United States from 1995 to 2002. METHODS: We performed a longitudinal analysis of the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey of adult visits to physicians in ambulatory clinics and emergency departments throughout the United States from 1995 to 2002. The main outcomes were fluoroquinolone prescribing rates and prescribing in accordance with Food and Drug Administration approval as of December 2002. RESULTS: Between 1995 and 2002, fluoroquinolones became the most commonly prescribed class of antibiotics to adults in the United States. Fluoroquinolone prescribing rose threefold, from 7 million visits in 1995 to 22 million visits in 2002 (P < 0.0001). Fluoroquinolone prescribing increased as a proportion of overall antibiotic prescribing (from 10% to 24%; P < 0.0001) and as a proportion of the U.S. population (from 39 to 106 prescriptions per 1000 adults; P < 0.001). These increases were due to the use of newer fluoroquinolones with activity against Streptococcus pneumoniae. Forty-two percent of fluoroquinolone prescriptions were for nonapproved diagnoses. Among patients receiving antibiotics, nonapproved fluoroquinolone prescribing increased over time (odds ratio = 1.18 per year; 95% confidence interval: 1.13 to 1.24). CONCLUSION: Fluoroquinolone prescribing increased threefold in outpatient clinics and emergency departments in the United States from 1995 to 2002. Fluoroquinolones became the most commonly prescribed class of antibiotics to adults in 2002. Nonapproved fluoroquinolone prescribing was common and increased over time. Such prescribing patterns are likely to be followed by an increasing prevalence of fluoroquinolone-resistant bacteria. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:259 / 268
页数:10
相关论文
共 51 条
[1]  
ALANIS A, 1992, POSTGRAD MED J, V68, pS24
[2]   Cultural and economic factors that (Mis)Shape antibiotic use: The nonpharmacologic basis of therapeutics [J].
Avorn, J ;
Solomon, DH .
ANNALS OF INTERNAL MEDICINE, 2000, 133 (02) :128-135
[3]  
BARNETT ED, 1995, PEDIATR CLIN N AM, V42, P509
[4]   BACTERIOLOGY OF MAXILLARY SINUSITIS IN RELATION TO CHARACTER OF INFLAMMATION AND PRIOR TREATMENT [J].
BERG, O ;
CARENFELT, C ;
KRONVALL, G .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1988, 20 (05) :511-516
[5]   Fluoroquinolone resistance in Streptococcus pneumoniae in United States since 1994-1995 [J].
Brueggemann, AB ;
Coffman, SL ;
Rhomberg, P ;
Huynh, H ;
Almer, L ;
Nilius, A ;
Flamm, R ;
Doern, GV .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :680-688
[6]  
*CDCP, 2001, MMWR-MORBID MORTAL W, V50, P800
[7]  
Centers for Disease Control and Prevention (CDC), 2002, MMWR Morb Mortal Wkly Rep, V51, P1041
[8]   Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada [J].
Chen, DK ;
McGeer, A ;
de Azavedo, JC ;
Low, DE .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :233-239
[9]  
CHERRY DK, 2003, VITAL HLTH STAT, V337
[10]   A physician survey of the effect of drug sample availability on physicians' behavior [J].
Chew, LD ;
O'Young, TS ;
Hazlet, TK ;
Bradley, KA ;
Maynard, C ;
Lessler, DS .
JOURNAL OF GENERAL INTERNAL MEDICINE, 2000, 15 (07) :478-483