First-principles and direct design approaches for the control of pharmaceutical crystallization

被引：258

作者：

Fujiwara, M ^{[1
]}

Nagy, ZK ^{[1
]}

Chew, JW ^{[1
]}

Braatz, RD ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

来源：

JOURNAL OF PROCESS CONTROL | 2005年 / 15卷 / 05期

基金：

美国国家科学基金会;

关键词：

pharmaceuticals processes; industrial crystallization; optimal control;

D O I：

10.1016/j.jprocont.2004.08.003

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Crystallization is the main separation and, purification process for the manufacturing of drug substances. Not only does crystallization affect the efficiency of downstream operations such as filtering, drying, and formulating, the efficacy of the drug can be dependent on the final crystal form. Advances in simulation and control algorithms and process sensor technologies have enabled the development of systematic first-principles and direct design approaches for the batch control of crystallization processes. These approaches address different challenges associated with pharmaceutical crystallization control. This paper provides an overview of recent technological advances in the in situ control of pharmaceutical crystallization processes. Implementation of the first-principles and direct design approaches are compared, and their relative merits are explained. Areas of future opportunities for application of advanced control strategies in pharmaceutical crystallization are presented. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：493 / 504

页数：12

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