Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

被引：38

作者：

Bergholdt, Regine ^{[1
]}

Storling, Zenia M. ^{[2
]}

Lage, Kasper ^{[2
]}

Karlberg, E. Olof ^{[2
]}

Olason, Pall I. ^{[2
]}

Aalund, Mogens ^{[3
]}

Nerup, Jorn ^{[1
,4
]}

Brunak, Soren ^{[2
]}

Workman, Christopher T. ^{[2
]}

Pociot, Flemming ^{[1
,4
]}

机构：

[1] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

[2] Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark

[3] Neurotech AS, DK-2100 Copenhagen, Denmark

[4] Lund Univ, Inst Clin Sci, SE-22100 Lund, Sweden

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 11期

关键词：

D O I：

10.1186/gb-2007-8-11-r253

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.

引用

页数：12

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