Polymorphonuclear Neutrophils and Cancer. Intense and Sustained Neutrophilia as a Treatment Against Solid Tumors

被引:71
作者
Carlos Souto, Juan [1 ]
Vila, Luis [2 ,4 ]
Bru, Antonio [3 ]
机构
[1] Hosp Santa Crue & Sant Pau, Dept Hematol, Barcelona 08025, Spain
[2] Hosp Santa Crue & Sant Pau, Lab Angiol Vasc Biol & Inflammat, Inst Res, Barcelona 08025, Spain
[3] Univ Complutense Madrid, Dept Appl Math, Fac Math, Madrid, Spain
[4] Hosp Santa Crue & Sant Pau, Dept Dermatol, Barcelona 08025, Spain
关键词
cancer; neutrophils; tumor growth; acute inflammation; innate immunity; COLONY-STIMULATING FACTOR; MEDIATED CYTO-TOXICITY; DEPENDENT CELLULAR CYTOTOXICITY; FC-GAMMA-RI; BACILLUS-CALMETTE-GUERIN; MAMMARY ADENOCARCINOMA CELLS; SUPERFICIAL BLADDER-CANCER; HOST-PARASITE INTERACTIONS; STREPTOCOCCAL PREPARATION OK-432; CHRONIC GRANULOCYTIC LEUKEMIA;
D O I
10.1002/med.20185
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and represent the first line of immune defense against infection. This review of the biomedical literature of the last 40 years shows that they also have a powerful antitumoral effect under certain circumstances. Typically, the microenvironment surrounding a solid tumor possesses many of the characteristics of chronic inflammation, a condition considered very favorable for tumor growth and spread. However, there are many circumstances that shift the chronic inflammatory state toward an acute inflammatory response around a tumor. This shift seems to convert PMN into very efficient anticancer effector cells. Clinical reports of unexpected antitumoral effects linked to the prolonged use of granulocyte colony-stimulating factor, which stimulates an intense and sustained neutrophilia, suggest that an easy way to fight solid tumors would be to encourage the development of intense peritumoral PMN infiltrates. Specifically designed clinical trials are urgently needed to evaluate the safety and efficacy of such drug-induced neutrophilia in patients with solid tumors. This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer. (C) 2009 Wiley Periodicals, Inc. Med Res Rev, 31, No. 3, 311-363, 2011
引用
收藏
页码:311 / 363
页数:53
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