Promoter polymorphisms of the CD14 gene are not associated with bronchial asthma in Caucasian children

被引：39

作者：

Heinzmann, A ^{[1
]}

Dietrich, H ^{[1
]}

Jerkic, SP ^{[1
]}

Kurz, T ^{[1
]}

Deichmann, KA ^{[1
]}

机构：

[1] Univ Freiburg, Univ Childrens Hosp, D-79106 Freiburg, Germany

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 2003年 / 30卷 / 05期

关键词：

D O I：

10.1046/j.1365-2370.2003.00414.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several studies have investigated the association of a promoter polymorphism in CD14 with atopic phenotypes. We screened this and another polymorphism in 182 asthmatic children and found no association with asthma. Furthermore, there was substantial linkage disequilibrium of the polymorphisms. Thus CD14 does not play a major role in the development of asthma in our population of Caucasian children.

引用

页码：345 / 348

页数：4

共 16 条

[1] A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E [J].

Baldini, M ;

Lohman, IC ;

Halonen, M ;

Erickson, RP ;

Holt, PG ;

Martinez, FD .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (05) :976-983

[2] New directions in allergic diseases: Mechanism-based anti-inflammatory therapies [J].

Barnes, PJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (01) :5-16

[3] Allergy to dermatophagoides in a group of Spanish gypsies:: Genetic restrictions [J].

Cárdaba, B ;

Moffatt, MF ;

Fernández, E ;

Jurado, A ;

Rojo, M ;

García, M ;

Ansotegui, IJ ;

Cortegano, I ;

Arrieta, I ;

Etxenagusia, MA ;

del Pozo, V ;

Urraca, J ;

Aceituno, E ;

Gallardo, S ;

Palomino, P ;

Cookson, W ;

Lahoz, C .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2001, 125 (04) :297-306

[4]

Gao PS, 1999, CLIN GENET, V56, P164

[5] A profile of the members of FASEB societies: NIH-awards, degrees, and institutional affiliations, 1999 [J].

Garrison, HH ;

Lahiri, S ;

Stephens, D .

FASEB JOURNAL, 2000, 14 (01) :2-5

[6] Atopic versus infectious diseases in childhood: a question of balance? [J].

Holt, PG ;

Sly, PD ;

Bjorksten, B .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 1997, 8 (02) :53-58

[7] Association of a promoter polymorphism of the CD14 gene and atopy [J].

Koppelman, GH ;

Reijmerink, NE ;

Stine, OC ;

Howard, TD ;

Whittaker, PA ;

Meyers, DA ;

Postma, DS ;

Bleecker, ER .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (04) :965-969

[8] Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children [J].

Lauener, RP ;

Birchler, T ;

Adamski, J ;

Braun-Fahrländer, C ;

Bufe, A ;

Herz, U ;

von Mutius, E ;

Nowak, D ;

Riedler, J ;

Waser, M ;

Sennhauser, FH .

LANCET, 2002, 360 (9331) :465-466

[9] A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity [J].

LeVan, TD ;

Bloom, JW ;

Bailey, TJ ;

Karp, CL ;

Halonen, M ;

Martinez, FD ;

Vercelli, D .

JOURNAL OF IMMUNOLOGY, 2001, 167 (10) :5838-5844

[10] LINKAGE ANALYSIS OF IL4 AND OTHER CHROMOSOME 5Q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN-E CONCENTRATIONS [J].

MARSH, DG ;

NEELY, JD ;

BREAZEALE, DR ;

GHOSH, B ;

FREIDHOFF, LR ;

EHRLICHKAUTZKY, E ;

SCHOU, C ;

KRISHNASWAMY, G ;

BEATY, TH .

SCIENCE, 1994, 264 (5162) :1152-1156

← 1 2 →