Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

被引：106

作者：

Bymaster, FP

Beedle, EE

Findlay, J

Gallagher, PT ^{[1
]}

Krushinski, JH

Mitchell, S

Robertson, DW

Thompson, DC

Wallace, L

Wong, DT

机构：

[1] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

[2] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.08.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta(TM)) has proven to be effective in clinical trials for the treatment of depression. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4477 / 4480

页数：4

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