Pharmaceutical prospects for RNA interference

被引：91

作者：

Schiffelers, RM

Woodle, MC

Scaria, P

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

[2] Intradigm Corp, Rockville, MD 20852 USA

来源：

PHARMACEUTICAL RESEARCH | 2004年 / 21卷 / 01期

关键词：

siRNA; RNA interference; drug delivery; nucleic acids; gene silencing;

D O I：

10.1023/B:PHAM.0000012145.49054.6c

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

RNA interference has proven to be a powerful tool in gene function validation. Recently, the first studies were published reporting a disease-modulating activity of the technique, suggesting a promise for RNA interference as a novel therapeutic strategy. This review discusses the recent advancements in realizing the clinical utility of RNA-interference.

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页码：1 / 7

页数：7

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