Synthesis of Supercritical crystallization processes

Supercritical crystallization using carbon dioxide has become a favorite alternative to conventional processes such as evaporative crystallization and antisolvent crystallization. Phase diagrams that show the regions where various phases are present can facilitate the design of such processes. Starting from a given process objective, a relevant phase diagram is generated to guide process synthesis and to determine feasible operating conditions. The approach is illustrated using two examples involving antisolvent and depressurization crystallization.