Development of a novel ionic support and its application in the ionic liquid phase assisted synthesis of a potent antithrombotic

被引：43

作者：

de Kort, M

Tuin, AW

Kuiper, S

Overkleeft, HS

van der Marel, GA

Buijsman, RC

机构：

[1] NV Organon, Lead Discovery Unit, NL-5340 BH Oss, Netherlands

[2] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

ionic liquid; supported chemistry; sulfonamide; multistep synthesis Tirofiban;

D O I：

10.1016/j.tetlet.2004.01.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of ironic support 1 and its application in the preparation of a set of amides and sulforamides is described. The potential of 1 is further exemplified by its use in a one-pot multistep ionic liquid phase assisted synthesis of tirofiban analogue 2. (C) 2001 Elsevier Ltd. All rights reserved.

引用

页码：2171 / 2175

页数：5

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