The role of eosinophils in inflammatory bowel disease

被引：75

作者：

Al-Haddad, S

Riddell, RH

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[2] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

来源：

GUT | 2005年 / 54卷 / 12期

关键词：

D O I：

10.1136/gut.2005.072595

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Numbers of activated eosinophils are higher in patients with active and inactive ulcerative colitis (UC) compared with controls, but higher in the quiescent than in the active phase, indicating that eosinophils may play diverse roles in the pathophysiology of inflammatory bowel disease (proinflammatory versus repair).

引用

收藏

页码：1674 / 1675

页数：2

相关论文

共 31 条

[1]

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2 [J].

Akers, IA ;

Parsons, M ;

Hill, MR ;

Hollenberg, MD ;

Sanjar, S ;

Laurent, GJ ;

McAnulty, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 278 (01) :L193-L201

[2]

Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells [J].

Berger, P ;

Perng, DW ;

Thabrew, H ;

Compton, SJ ;

Cairns, JA ;

McEuen, AR ;

Marthan, R ;

De Lara, JMT ;

Walls, AF .

JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (03) :1372-1379

[3]

Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease [J].

Bischoff, SC ;

Wedemeyer, J ;

Herrmann, A ;

Meier, PN ;

Trautwein, C ;

Cetin, Y ;

Maschek, H ;

Stolte, M ;

Gebel, M ;

Manns, MP .

HISTOPATHOLOGY, 1996, 28 (01) :1-13

[4]

Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease [J].

Carvalho, ATP ;

Elia, CCS ;

de Souza, HSP ;

Elias, PRP ;

Pontes, EL ;

Lukashok, HP ;

de Freitas, FCD ;

Silva, JRLE .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2003, 36 (02) :120-125

[5]

Increased serum levels of eotaxin in patients with inflammatory bowel disease [J].

Chen, W ;

Paulus, B ;

Shu, D ;

Wilson, I ;

Chadwick, V .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2001, 36 (05) :515-520

[6]

Cloning, expression, and characterization of the human eosinophil eotaxin receptor [J].

Daugherty, BL ;

Siciliano, SJ ;

DeMartino, JA ;

Malkowitz, L ;

Sirotina, A ;

Springer, MS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (05) :2349-2354

[7]

Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis [J].

Desreumaux, P ;

Bloget, F ;

Seguy, D ;

Capron, M ;

Cortot, A ;

Colombel, JF ;

Janin, A .

GASTROENTEROLOGY, 1996, 110 (03) :768-774

[8]

CROHNS-DISEASE - TRANSMISSION ELECTRON-MICROSCOPIC STUDIES .2. IMMUNOLOGICAL INFLAMMATORY RESPONSE - ALTERATIONS OF MAST-CELLS, BASOPHILS, EOSINOPHILS, AND THE MICROVASCULATURE [J].

DVORAK, AM ;

MONAHAN, RA ;

OSAGE, JE ;

DICKERSIN, GR .

HUMAN PATHOLOGY, 1980, 11 (06) :606-619

[9]

Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase [J].

Forbes, E ;

Murase, T ;

Yang, M ;

Matthaei, KI ;

Lee, JJ ;

Lee, NA ;

Foster, PS ;

Hogan, SP .

JOURNAL OF IMMUNOLOGY, 2004, 172 (09) :5664-5675

[10]

Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia [J].

GarciaZepeda, EA ;

Rothenberg, ME ;

Ownbey, RT ;

Celestin, J ;

Leder, P ;

Luster, AD .

NATURE MEDICINE, 1996, 2 (04) :449-456

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