Stimulation of human keratinocyte growth by alginate oligosaccharides, a possible co-factor for epidermal growth factor in cell culture

被引:101
作者
Kawada, A
Hiura, N
Shiraiwa, M
Tajima, S
Hiruma, M
Hara, K
Ishibashi, A
Takahara, H
机构
[1] MARUHA CORP,CENT RES INST,TSUKUBA,IBARAKI,JAPAN
[2] IBARAKI UNIV,SCH AGR,DEPT BIORESOURCE SCI,AMI,IBARAKI 30003,JAPAN
[3] NAGASAKI UNIV,FAC FISHERIES,MARINE BIOCHEM LAB,NAGASAKI 852,JAPAN
关键词
alginate oligosaccharide; keratinocyte; proliferation; epidermal growth factor; bovine pituitary extract;
D O I
10.1016/S0014-5793(97)00386-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oligosaccharides, involved in regulation of plant developmental and defensive processes, were tested to determine their ability to enhance proliferation of human keratinocytes. A mixture of alginate oligosaccharides remarkably stimulated keratinocyte growth and [H-3]thymidine uptake in the presence of epidermal growth factor (EGP). The activity was comparable to bovine pituitary extract, a common complement in keratinocyte culture, and additive on BPE-induced stimulation. The most effective oligosaccharide in the mixture was identified and its chemical structure was determined. These findings demonstrate a novel activity of alginate oligosaccharide(s) in keratinocyte growth and suggest a possible co-factor for EGF-dependent stimulation in medium for keratinocytes. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:43 / 46
页数:4
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