Association of premature ventricular complexes with central aortic pressure indices and pulse wave velocity

被引:10
作者
Chen, Ju-Yi [1 ,2 ]
Tsai, Wei-Chuan [1 ]
Lee, Yung-Ling [3 ]
Lee, Cheng-Han [1 ]
Tsai, Liang-Miin [1 ]
Chao, Ting-Hsing [1 ]
Li, Yi-Heng [1 ]
Chen, Jyh-Hong [1 ]
Lin, Li-Jen [1 ]
机构
[1] Natl Cheng Kung Univ Hosp, Dept Internal Med, Div Cardiol, Tainan 704, Taiwan
[2] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 70101, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Occupat & Environm Med, Tainan 704, Taiwan
关键词
D O I
10.1016/j.ahj.2007.11.033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Although premature ventricular complex (PVC) occurs frequently, its predisposing factors have rarely been studied. We examined the connection between PVC and aortic stiffness. Methods We recruited 200 consecutive patients (<50 years, 95 men, mean age 36 10 years) who received a 24-hour ambulatory electrocardiography examination for palpitation and PVC loads. Muscular artery pulse wave velocity (PWVm) and 4 main aortic pressure indices-augmented pressure, augmentation index (Al-x), Al-x corrected for a steady heart rate of 75 beat/min, and the extra workload-were measured, and atherosclerosis risk was evaluated. Results Eighty-three (42%) patients had no PVC loads; 58 (29%) patients had low loads (<24 beat/d), and 59 (29%) had high loads (>= 24 beat/d). Only age and hyperlipidemia were significantly associated with PVC loads. Using a multivariate logistic regression model adjusted for potential confounders, we found that Al-x (odds ratio [OR] 1.88, 95% CI 1.20-2.91, P = .005); augmented pressure (OR 1.57, 95% CI 1.02-2.43, P = .042); Al-x corrected for a steady heart rate of 75 beat/min (OR 1.82, 95% CI 1.18-2.82, P = .007); and PWVm (OR 1.53, 95% CI 1.07-2.19, P = .021) were independent factors for PVC loads. Conclusion Increased central aortic pressure indices as well as PWVm were associated with increased PVC loads in young patients undergoing 24-hour ambulatory electrocardiography. Central aortic properties probably contributed to the occurrence of PVC.
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收藏
页码:500.e1 / 500.e6
页数:6
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