Tandem nucleophilic addition/cyclization reaction in the synthesis of ketimine-type iminosugars

被引：12

作者：

Behr, Jean-Bernard ^{[1
]}

Kalla, Adel ^{[1
]}

Harakat, Dominique ^{[1
]}

Plantier-Royon, Richard ^{[1
]}

机构：

[1] CNRS, UFR Sci, ICMR, F-51687 Reims 2, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 09期

关键词：

D O I：

10.1021/jo702616x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biological activity of unsaturated iminosugars has not yet been extensively studied because of a lack of general synthetic methods. A practical synthesis of these cyclic ketimine sugars was developed, which was based on a tandem addition-cyclization reaction of a Grignard reagent to a omega-methanesulfonylglycononitrile.

引用

页码：3612 / 3615

页数：4

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