Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

被引：26

作者：

Brock, Kaye E. ^{[1
]}

Huang, Wen-Yi ^{[2
]}

Fraser, David R. ^{[3
]}

Ke, Liang ^{[1
,4
]}

Tseng, Marilyn ^{[5
]}

Mason, Rebecca S. ^{[6
]}

Stolzenberg-Solomon, Rachael Z. ^{[2
]}

Freedman, D. Michal ^{[2
]}

Ahn, Jiyoung ^{[7
]}

Peters, Ulrike ^{[8
]}

McCarty, Catherine ^{[9
]}

Hollis, Bruce W. ^{[10
]}

Ziegler, Regina G. ^{[2
]}

Purdue, Mark P. ^{[2
]}

Graubard, Barry I. ^{[2
]}

机构：

[1] Univ Sydney, Fac Hlth Sci, Lidcombe, NSW, Australia

[2] NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA

[3] Univ Sydney, Fac Vet Sci, Camperdown, NSW, Australia

[4] George Inst, Dept Res & Dev, Beijing, Peoples R China

[5] Calif Polytech State Univ San Luis Obispo, Dept Kinesiol, San Luis Obispo, CA 93407 USA

[6] Univ Sydney, Fac Med, Bosch Inst, Camperdown, NSW, Australia

[7] NYU Sch Med, Dept Environm Med, Div Epidemiol, New York, NY USA

[8] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[9] Marshfield Clin Res Fdn, Marshfield, WI USA

[10] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA

来源：

BRITISH JOURNAL OF NUTRITION | 2011年 / 106卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Diabetes; Vitamin D status; 25-Hydroxyvitamin D; 1,25-Dihydroxyvitamin D; VITAMIN-D STATUS; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; D DEFICIENCY; INSULIN; ADULTS; HEALTH; RADIOIMMUNOASSAY; CALCIUM;

D O I：

10.1017/S0007114511001590

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hypovitaminosis D may be associated with diabetes, hypertension and CHD. However, because studies examining the associations of all three chronic conditions with circulating 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) are limited, we examined these associations in the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (n 2465). Caucasian PLCO participants selected as controls in previous nested case control studies of 25(OH)D and 1,25(OH)(2)D were included in this analysis. Diabetes, CHD and hypertension prevalence, risk factors for these conditions and intake of vitamin 1) and Ca were collected from a baseline questionnaire. Results indicated that serum levels of 25(OH)D were low (<50 nmol/l) in 29% and very low (<37 nmol/l) in 11% of subjects. The prevalence of diabetes, hypertension and CHD was 7, 30 and 10%, respectively. After adjustment for confounding by sex, geographical location, educational level, smoking history, BMI, physical activity, total dietary energy and vitamin D and Ca intake, only diabetes was significantly associated with lower 25(OH)D and 1,25(OH)(2)D levels. Caucasians who had 25(OH)D >= nmol/l were half as likely to have diabetes (OR 0.5 (95% CI 0.3, 0.9)) compared with those who had 25(OH)D <37 nmol/l. Those in the highest quartile of 1,25(OH)(2)D (>= 103 pmol/l) were less than half as likely to have diabetes (OR 0.3 (95% Cl 0.1, 0.7)) than those in the lowest quartile (<72 pmol/l). In conclusion, the independent associations of 25(OH)D and 1,25(OH)(2)D with diabetes prevalence in a large population are new findings, and thus warrant confirmation in larger, prospective studies.

引用

页码：339 / 344

页数：6

共 24 条

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