A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons

被引：54

作者：

Arteaga, Maria F. ^{[1
]}

Coric, Tatjana ^{[1
]}

Straub, Christoph ^{[1
]}

Canessa, Cecilia M. ^{[1
]}

机构：

[1] Yale Univ, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 11期

关键词：

alternative promoter; proton-activated channel; serum- and glucocorticoid-induced kinase;

D O I：

10.1073/pnas.0800958105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1.1, which exhibits distinct regulation, properties, and functional effects. SGK1.1 decreases expression of the acid-sensing ion channel-1 (ASIC1); thereby, SGK1.1 may limit neuronal injury associated to activation of ASIC1 in ischemia. Given that neurons express at least two splice isoforms, SGK1 and SGK1.1, driven by distinct promoters, any changes in SGK1 transcript level must be examined to define the isoform induced by each stimulus or neurological disorder.

引用

收藏

页码：4459 / 4464

页数：6

相关论文

共 31 条

[1]

Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1 [J].

Arteaga, Maria Francisca ;

de la Rosa, Diego Alvarez ;

Alvarez, Jose A. ;

Canessa, Cecilia M. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (06) :2072-2080

[2]

An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery [J].

Arteaga, Maria Francisca ;

Wang, Lin ;

Ravid, Tommer ;

Hochstrasser, Mark ;

Canessa, Cecilia M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11178-11183

[3]

A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway [J].

Bogusz, Agata M. ;

Brickley, Deanna R. ;

Pew, Travis ;

Conzen, Suzanne D. .

FEBS JOURNAL, 2006, 273 (13) :2913-2928

[4]

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) [J].

Brunet, A ;

Park, J ;

Tran, H ;

Hu, LS ;

Hemmings, BA ;

Greenberg, ME .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (03) :952-965

[5]

Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: Activation of Akt and inactivation of SGK1 [J].

Chao, Chih C. ;

Ma, Yun L. ;

Lee, Eminy H. Y. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (23) :6243-6248

[6]

Epithelial sodium channel regulated by aldosterone-induced protein sgk [J].

Chen, SY ;

Bhargava, A ;

Mastroberardino, L ;

Meijer, OC ;

Wang, J ;

Buse, P ;

Firestone, GL ;

Verrey, F ;

Pearce, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2514-2519

[7]

The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1 [J].

Coric, T ;

Zhang, P ;

Todorovic, N ;

Canessa, CM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45240-45247

[8]

Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity [J].

Firestone, GL ;

Giampaolo, JR ;

O'Keeffe, BA .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2003, 13 (01) :1-12

[9]

A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states [J].

Geranton, Sandrine M. ;

Morenilla-Palao, Cruz ;

Hunt, Stephen P. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (23) :6163-6173

[10]

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane [J].

Heo, Won Do ;

Inoue, Takanari ;

Park, Wei Sun ;

Kim, Man Lyang ;

Park, Byung Ouk ;

Wandless, Thomas J. ;

Meyer, Tobias .

SCIENCE, 2006, 314 (5804) :1458-1461

← 1 2 3 4 →