Inhibitory effects of fluvastain and its metabolites on the formation of several reactive oxygen species

被引：44

作者：

Nakashima, A

Ohtawa, M

Iwasaki, K

Wada, M

Kuroda, N

Nakashima, K

机构：

[1] Novartis Pharma KK, Res Inst, Tsukuba, Ibaraki 3002611, Japan

[2] Nagasaki Univ, Sch Pharmaceut Sci, Nagasaki 8528521, Japan

[3] Nagasaki Univ, Grad Sch Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

LIFE SCIENCES | 2001年 / 69卷 / 12期

关键词：

oxidative stress; antioxidant; HMG-CoA reductase inhibitor; fluvastatin; metabolite; reactive oxygen species;

D O I：

10.1016/S0024-3205(01)01223-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We investigated the inhibitory effects of fluvastain (FV) and its metabolites (M-2, M-3, M-4, M-5, and M-7) on the formation of several reactive oxygen species (ROS), such as singlet oxygen (O-1(2)), superoxide anion (O-2(-)), hydroxy radical ((OH)-O-.), hypochlorite ion (OCL-, and linoleic acid peroxide (LOO.). Inhibitory effects of pravastatin (PV), simvastatin (SV), probucol (PR) and alpha -tocopherol (TOC) were also tested. The inhibitory effects of 5-hydroxy FV (M-2) and 6-hydroxy FV (M-3) on the formation of O-1(2), O-2(-), (OH)-O-., and OCL- were strongest. Scavenging of O-1(2) by M-4, M-5, (+)-FV, and (-)-FV was also noted. The inhibitory effects of (+)-FV on the formation Of O-1(2) were comparable to those of (-)-FV. PV, SV, PR and M-7 had little or no inhibitory effect on the formation of several ROS. In conclusion, FV and its metabolites, particulary M-2 and M-3, have the potential to protect against oxidative stress mediated by several ROS. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1381 / 1389

页数：9

共 27 条

[1]

Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: Antiatherogenic effects of HMG-CoA reductase inhibitor therapy [J].