Lifecourse socioeconomic position, C-reactive protein, and carotid intima-media thickness in young adults -: The Cardiovascular Risk in Young Finns Study

被引:73
作者
Kivimäki, M
Lawlor, DA
Juonala, M
Smith, GD
Elovainio, M
Keltikangas-Järvinen, L
Vahtera, J
Viikari, JSA
Raitakari, OT
机构
[1] Finnish Inst Occupat Hlth, FIN-00250 Helsinki, Finland
[2] Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland
[3] Univ Bristol, Dept Social Med, Bristol BS8 1TH, Avon, England
[4] Univ Turku, Dept Med, SF-20500 Turku, Finland
[5] Univ Turku, Dept Clin Physiol, SF-20500 Turku, Finland
[6] Univ Turku, Cardiovasc Res Unit, SF-20500 Turku, Finland
关键词
inflammation; atherosclerosis; socioeconomic; risk factors; epidemiology;
D O I
10.1161/01.ATV.0000183729.91449.6e
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective - It has been suggested that confounding by socioeconomic position from across the lifecourse together with adult risk factors explain the association between C-reactive protein (CRP) and coronary heart disease, but the evidence for this is limited to elderly subjects. We examined associations between socioeconomic position in childhood and adulthood, adult CRP, and carotid intima-media thickness (IMT), a presymptomatic predictor of coronary heart disease, in a population of young adults. Methods and Results - The association of socioeconomic indicators at age 3 to 18 and in adulthood with CRP and IMT at age 24 to 39 were examined in a prospective cohort study of 2290 ( 1030 men and 1260 women) participants in the Young Finns Study. After adjustment for age and sex, both childhood and adulthood socioeconomic position were inversely associated with CRP ( ps <= 0.02). There was also a direct correlation between CRP and IMT ( P < 0.008). However, both the association between socioeconomic position and CRP and that between CRP and IMT attenuated to the null with adjustment for BMI and waist-to-hip ratio. Controlling for other risk factors had little effect on these associations. Conclusions - In young adults, the interrelations between socioeconomic position, CRP, and carotid atherosclerosis are accounted for by adiposity.
引用
收藏
页码:2197 / 2202
页数:6
相关论文
共 33 条
[1]   C-reactive protein and atherosclerosis of the thoracic aorta - A population-based transesophageal echocardiographic study [J].
Agmon, Y ;
Khandheria, BK ;
Meissner, I ;
Petterson, TM ;
O'Fallon, WM ;
Wiebers, DO ;
Christianson, TJH ;
McConnell, JP ;
Whisnant, JP ;
Seward, JB ;
Tajik, AJ .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (16) :1781-1787
[2]   CARDIOVASCULAR RISK IN YOUNG FINNS [J].
AKERBLOM, HK ;
UHARI, M ;
PESONEN, E ;
DAHL, M ;
KAPRIO, EA ;
NUUTINEN, EM ;
PIETIKAINEN, M ;
SALO, MK ;
AROMAA, A ;
KANNAS, L ;
KELTIKANGASJARVINEN, L ;
KUUSELA, V ;
RASANEN, L ;
RONNEMAA, T ;
KNIP, M ;
TELAMA, R ;
VALIMAKI, I ;
PYORALA, K ;
VIIKARI, J .
ANNALS OF MEDICINE, 1991, 23 (01) :35-39
[3]  
BATTY GD, IN PESS J EPIDEMIOLO
[4]   Relationship of periodontal disease to carotid artery intima-media wall thickness - The atherosclerosis risk in communities (ARIC) study [J].
Beck, JD ;
Elter, JR ;
Heiss, G ;
Couper, D ;
Mauriello, SM ;
Offenbacher, S .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (11) :1816-1822
[5]   ELEVATION OF C-REACTIVE PROTEIN IN ACTIVE CORONARY-ARTERY DISEASE [J].
BERK, BC ;
WEINTRAUB, WS ;
ALEXANDER, RW .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (03) :168-172
[6]   C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease [J].
Danesh, J ;
Wheeler, JG ;
Hirschfield, GM ;
Eda, S ;
Eiriksdottir, G ;
Rumley, A ;
Lowe, GDO ;
Pepys, MB ;
Gudnason, V .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (14) :1387-1397
[7]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[8]   Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences [J].
Greenfield, JR ;
Samaras, K ;
Jenkins, AB ;
Kelly, PJ ;
Spector, TD ;
Gallimore, JR ;
Pepys, MB ;
Campbell, LV .
CIRCULATION, 2004, 109 (24) :3022-3028
[9]   INTERLEUKIN-6 AND THE ACUTE PHASE RESPONSE [J].
HEINRICH, PC ;
CASTELL, JV ;
ANDUS, T .
BIOCHEMICAL JOURNAL, 1990, 265 (03) :621-636
[10]  
Hulthe J, 2001, CLIN SCI, V100, P371, DOI [10.1042/CS20000269, 10.1042/cs1000371]