Matrix metalloproteinases at cancer tumor-host interface

被引：188

作者：

Noel, Agnes ^{[1
]}

Jost, Maud ^{[1
]}

Maquoi, Erik ^{[1
]}

机构：

[1] Univ Liege, GIGA R, CRCE, Lab Tumour & Dev Biol, B-4000 Liege, Belgium

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2008年 / 19卷 / 01期

关键词：

stromal proteases; cancer invasion; angiogenesis; inflammation;

D O I：

10.1016/j.semcdb.2007.05.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The increasing diversity in both substrates and functions of matrix metalloproteinases ( MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：52 / 60

页数：9

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