Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer

被引：79

作者：

Freeman, MR ^{[1
]}

Cinar, B

Lu, ML

机构：

[1] Childrens Hosp, Dept Neurol, Urol Dis Res Ctr, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tem.2005.06.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence indicates that nuclear receptors for steroid hormones can signal by nongenomic mechanisms that operate independently of their transcription function. These signal-transduction processes occur within seconds to minutes after initiation with agonist and involve interactions between nuclear receptors and other signaling proteins in the cytoplasm and at membrane surfaces. This review provides an overview of published information on possible nongenomic activities of the androgen receptor (AR) and other nuclear receptors, focusing on the potential involvement of these processes in prostate cancer. We discuss the hypothesis that the cholesterol-rich lipid-raft compartment(s) of cancer-cell membranes might provide privileged sites for nongenomic signals mediated by the AR.

引用

页码：273 / 279

页数：7

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