Polymers in drug delivery

被引：485

作者：

Pillai, O ^{[1
]}

Panchagnula, R ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, SAS Nagar 160062, Punjab, India

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00227-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in polymer science have led to the development of several novel drug-delivery sytems. A proper consideration of surface and bulk properties can aid in the designing of polymers for various drug-delivery applications. Biodegradable polymers find widespread use in drug delivery as they can be degraded to non-toxic monomers inside the body. Novel supramolecular structures based on polyethylene oxide copolymers and dendrimers are being intensively researched for delivery of genes and macromolecules. Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems. Design and synthesis of novel combinations of polymers will expand the scope of new drug-delivery systems in the future.

引用

页码：447 / 451

页数：5

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