Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

被引：116

作者：

Williams, JV

Crowe, JE

Enriquez, R

Minton, P

Peebles, RS

Hamilton, RG

Higgins, S

Griffin, M

Hartert, TV

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Allergy Pulm & Crit Care Med,Ctr Hlth Serv Re, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN 37232 USA

[5] Johns Hopkins Univ, Sch Med, Div Clin Immunol, Baltimore, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 07期

关键词：

D O I：

10.1086/444392

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up ( odds ratio, 7 [95% confidence interval, 0.9-312]; P = 0.3). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

引用

页码：1149 / 1153

页数：5

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