Synthetic Bio-nanoreactor: Mechanical and Chemical Control of Polymersome Membrane Permeability

被引：252

作者：

Gaitzsch, Jens ^{[2
,3
]}

Appelhans, Dietmar ^{[2
]}

Wang, Linge ^{[1
]}

Battaglia, Giuseppe ^{[1
]}

Voit, Brigitte ^{[2
,3
]}

机构：

[1] Univ Sheffield, Dept Biomed Sci, Western Bank, Sheffield S10 2TN, S Yorkshire, England

[2] Leibniz Inst Polymerforsch Dresden eV, D-01069 Dresden, Germany

[3] Tech Univ Dresden, Fachrichtung Chem & Lebensmittelchem, D-01062 Dresden, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 18期

关键词：

bio-nanoreactors; membranes; polymersomes; poration; shear force;

D O I：

10.1002/anie.201108814

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

pH-sensitive polymersomes have been stabilized by UV cross-linking after incorporation of an enzyme in a synthetic bio-nanoreactor without transmembrane proteins. This stabilization allows the reversible swelling and deswelling of the polymersomes upon changes in the pH value. The controlled reaction of the enclosed enzyme could be monitored selectively at pH 6, when the substrate could penetrate the membrane. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4448 / 4451

页数：4

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