Alternative bisphosphonate targets and mechanisms of action

被引：59

作者：

Bukowski, JF ^{[1
]}

Dascher, CC ^{[1
]}

Das, H ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med,Div Rheumatol Immunol & Allergy, Dept Med,Lymphocyte Biol Sect, Boston, MA 02115 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 03期

关键词：

D O I：

10.1016/j.bbrc.2004.11.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the number of bisphosphonates continues to increase, they have found widespread use in an increasing number of clinical conditions. Ongoing examination of their targets and mechanisms of action has revealed that this surprisingly diverse class of drugs has effects beyond those first described for osteoclasts. These additional targets include osteoblasts, osteocytes, angiogenesis, and gammadelta T lymphocytes of the human immune system. The immune system effects are specifically targeted to gammadelta T cells and are reminiscent of the effects seen after ingestion of tea beverage. BP effects on such alternate targets may explain not only their antiresorptive effect, but also their effect on bone quality, tumors, and microbes. (C) 2004 Elsevier Inc. All rights reserved.

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页码：746 / 750

页数：5

相关论文

共 36 条

[1] Etidronate inhibits human osteoblast apoptosis by inhibition of pro-apoptotic factor(s) produced by activated T cells [J].

Abe, Y ;

Kawakami, A ;

Nakashima, T ;

Ejima, E ;

Fujiyama, K ;

Kiriyama, T ;

Ide, A ;

Sera, N ;

Usa, T ;

Tominaga, T ;

Ashizawa, K ;

Yokoyama, N ;

Eguchi, K .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2000, 136 (05) :344-354

[2] Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death -: Evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt [J].

Bezzi, M ;

Hasmim, M ;

Bieler, G ;

Dormond, O ;

Rüegg, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) :43603-43614

[3] Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea:: Implications for innate immunity [J].

Bukowski, JF ;

Morita, CT ;

Brenner, MB .

IMMUNITY, 1999, 11 (01) :57-65

[4] Habitual tea consumption and risk of osteoporosis: A prospective study in the women's health initiative observational cohort [J].

Chen, Z ;

Pettinger, MB ;

Ritenbaugh, C ;

LaCroix, AZ ;

Robbins, J ;

Caan, BJ ;

Barad, DH ;

Hakim, IA .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 158 (08) :772-781

[5]

Coxon FP, 1998, MOL PHARMACOL, V54, P631

[6] Etidronate (HEBP) promotes osteoblast differentiation and wound closure in rat calvaria [J].

D'Aoust, P ;

McCulloch, CAG ;

Tenenbaum, HC ;

Lekic, PC .

CELL AND TISSUE RESEARCH, 2000, 302 (03) :353-363

[7] Vγ2Vδ2 T-cell receptor-mediated recognition of aminobisphosphonates [J].

Das, H ;

Wang, LS ;

Kamath, A ;

Bukowski, JF .

BLOOD, 2001, 98 (05) :1616-1618

[8]

Fournier P, 2002, CANCER RES, V62, P6538

[9] Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo [J].

Giuliani, N ;

Pedrazzoni, M ;

Negri, G ;

Passeri, G ;

Impicciatore, M ;

Girasole, G .

BONE, 1998, 22 (05) :455-461

[10]

Giuliani N, 1998, SCAND J RHEUMATOL, V27, P38

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