Characterization of the low-copy HERV-Fc family:: evidence for recent integrations in primates of elements with coding envelope genes

被引:43
作者
Bénit, L [1 ]
Calteau, A [1 ]
Heidmann, T [1 ]
机构
[1] Inst Gustave Roussy, Unite Retrovirus Endogenes & Elements Retroides E, CNRS, UMR 8122, F-94805 Villejuif, France
关键词
HERV; retrovirus; envelope; phylogeny; primate;
D O I
10.1016/S0042-6822(03)00163-6
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In a previous search based on the envelope gene, we had identified two related proviral elements that could not be included in identified ERV families. An in silico database screening associated with an in vivo polymerase chain reaction search using primers in the reverse transcriptase domain, now allowed identification of a series of related elements, found at a limited number in simians. A phylogenetic analysis led to their inclusion in a new family of endogenous retroviruses with limited expansion, which we named ERV-Fc, and which is part of the enlarged ERV-F/H family. The human genome comprises only six HERV-Fc, among which two possess full-length coding envelope genes. A complete provirus was identified in the baboon, also disclosing a fully open envelope gene. Cloning of the sites orthologous to the envelope-coding human proviruses demonstrated presence of the integrated proviruses in chimpanzee and gorilla, but not in orangutan. For the baboon element, the orthologous locus was found empty even in the phylogenetically most closely related macaque, again suggestomg, together with the complete identity of its LTRs, "recent" integration. The data presented are compatible with an evolutionary scheme in which the ERV-Fc proviruses would be the endogenous traces of an active retroviral element, possibly acting as an infectious retrovirus with low endogeneization potency, with evidence for integrations at two distinct periods of primate evolution. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:159 / 168
页数:10
相关论文
共 26 条
[1]   Comparative analyses of LTRs of the ERV-H family of primate-specific retrovirus-like elements isolated from marmoset, African green monkey, and man [J].
Anderssen, S ;
Sjottem, E ;
Svineng, G ;
Johansen, T .
VIROLOGY, 1997, 234 (01) :14-30
[2]  
Benit L, 1997, J VIROL, V71, P5652
[3]   Identification, phylogeny, and evolution of retroviral elements based on their envelope genes [J].
Bénit, L ;
Dessen, P ;
Heidmann, T .
JOURNAL OF VIROLOGY, 2001, 75 (23) :11709-11719
[4]   Endogenous retroviruses and the evolution of resistance to retroviral infection [J].
Best, S ;
LeTissier, PR ;
Stoye, JP .
TRENDS IN MICROBIOLOGY, 1997, 5 (08) :313-318
[5]   An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor [J].
Blond, JL ;
Lavillette, D ;
Cheynet, V ;
Bouton, O ;
Oriol, G ;
Chapel-Fernandes, S ;
Mandrand, B ;
Mallet, F ;
Cosset, FL .
JOURNAL OF VIROLOGY, 2000, 74 (07) :3321-3329
[6]  
Boeke J. D., 1997, P343
[7]   ISOLATION OF NOVEL HUMAN ENDOGENOUS RETROVIRUS-LIKE ELEMENTS WITH FOAMY VIRUS-RELATED POL SEQUENCE [J].
CORDONNIER, A ;
CASELLA, JF ;
HEIDMANN, T .
JOURNAL OF VIROLOGY, 1995, 69 (09) :5890-5897
[8]   Characterization of the three HERV-H proviruses with an open envelope reading frame encompassing the immunosuppressive domain and evolutionary history in primates [J].
de Parseval, N ;
Casella, JF ;
Gressin, L ;
Heidmann, T .
VIROLOGY, 2001, 279 (02) :558-569
[9]   RIBOSOMAL FRAMESHIFTING EFFICIENCY AND GAG GAG-POL RATIO ARE CRITICAL FOR YEAST M(1) DOUBLE-STRANDED-RNA VIRUS PROPAGATION [J].
DINMAN, JD ;
WICKNER, RB .
JOURNAL OF VIROLOGY, 1992, 66 (06) :3669-3676
[10]   Constructing primate phylogenies front ancient retrovirus sequences [J].
Johnson, WE ;
Coffin, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10254-10260