Palladium catalysis in bridge-forming reactions between stereoselectively substituted glycine auxiliaries.

被引：23

作者：

Moller, BS ^{[1
]}

Benneche, T ^{[1
]}

Undheim, K ^{[1
]}

机构：

[1] UNIV OSLO,DEPT CHEM,N-0315 OSLO,NORWAY

来源：

TETRAHEDRON | 1996年 / 52卷 / 26期

关键词：

D O I：

10.1016/0040-4020(96)00422-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The disulfide bridge in cystine has formally been replaced by substitution of two a-alanines at the beta-carbon into the 2,3-positions in 1,3-butadiene. The key reactions are stereoselective alkylation of lithiated (2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine with 2,3-dibromopropene. The alkene-alkene bond formation was effected by Pd-catalysis either with the 2'-bromoallyl products from the alkylation as substrate or with the corresponding amino acid appropriately protected. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8807 / 8812

页数：6

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[2]

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[3]

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[4]

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