Metformin-induced lactic acidosis associated with acute renal failure

被引：26

作者：

Safadi, R ^{[1
]}

DranitzkiElhalel, M ^{[1
]}

Popovtzer, M ^{[1
]}

BenYehuda, A ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED CTR,DEPT HYPERTENS & NEPHROL,IL-91120 JERUSALEM,ISRAEL

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1996年 / 16卷 / 06期

关键词：

metformin; lactic acidosis; renal failure; urea cycle;

D O I：

10.1159/000169052

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis. There was a discrepancy between the patient's elevated serum creatinine level, indicative of severe renal insufficiency, and her very low Lactic acidosis blood urea nitrogen content. It is postulated that the patient's extremely severe acidosis interfered with her hepatic urea generation, contributing to this unusual biochemical abnormality.

引用

页码：520 / 522

页数：3

共 13 条

[1] PATHO-PHYSIOLOGY OF EXPERIMENTAL LACTIC-ACIDOSIS IN DOGS [J].

ARIEFF, AI ;

PARK, R ;

LEACH, WJ ;

LAZAROWITZ, VC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 239 (02) :F135-F142

[2]

ARIEFF AL, 1989, DIABETES METAB REV, V5, P627

[3] PHENFORMIN-INDUCED LACTIC ACIDOSIS IN DIABETIC-PATIENTS [J].

ASSAN, R ;

HEUCLIN, C ;

GIRARD, JR ;

LEMAIRE, F ;

ATTALI, JR .

DIABETES, 1975, 24 (09) :791-800

[4] EPIDEMIOLOGY OF ADVERSE DRUG-REACTIONS TO PHENFORMIN AND METFORMIN [J].

BERGMAN, U ;

BOMAN, G ;

WIHOLM, BE .

BRITISH MEDICAL JOURNAL, 1978, 2 (6135) :464-466

[5]

DAVIDOFF F, 1973, NEW ENGL J MED, V289, P141

[6] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].

EICHELBAUM, M ;

SPANNBRUCKER, N ;

STEINCKE, B ;

DENGLER, HJ .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187

[7] THE GENETIC-CONTROL OF SPARTEINE AND DEBRISOQUINE METABOLISM IN MAN WITH NEW METHODS OF ANALYZING BIMODAL DISTRIBUTIONS [J].

EVANS, DAP ;

HARMER, D ;

DOWNHAM, DY ;

WHIBLEY, EJ ;

IDLE, JR ;

RITCHIE, J ;

SMITH, RL .

JOURNAL OF MEDICAL GENETICS, 1983, 20 (05) :321-329

[8]

GUDER WG, 1987, J CLIN CHEM CLIN BIO, V25, P457

[9]

HERMANN LS, 1992, INT TXB DIABETES MEL, P773

[10]

KRIESBERG R, 1983, J CLIN ENDOCR METAB, V12, P391

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