Constitutive neutrophil apoptosis: Mechanisms and regulation

被引：227

作者：

Luo, Hongbo R. ^{[1
,2
,3
]}

Loison, Fabien ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Cambridge, MA 02138 USA

[2] Childrens Hosp, Joint Program Tranfus Med, Stem Cell Program, Dept Lab Med, Boston, MA 02115 USA

[3] Dana Farber Harvard Canc Ctr, Boston, MA USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2008年 / 83卷 / 04期

关键词：

D O I：

10.1002/ajh.21078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neutrophil constitutive death is a critical cellular process for modulating neutrophil number and function, and it plays an essential role in neutrophil homeostasis and the resolution of inflammation. Neutrophils die due to programmed cell death or apoptosis. In this article, we review recent studies on the mechanism of neutrophil apoptosis. The involvement of caspase, calpain, reactive oxygen species, cellular survival/death signaling pathways, mitochondria, and BCL-2 family member proteins are discussed. The fate of neutrophils can be influenced within the inflammatory microenvironment. We summarize the current understanding regarding the modulation of neutrophil apoptotic death by various extracellular stimuli such as proinflammatory cytokines, cell adhesion, phagocytosis, red blood cells, and platelets. The involvement of neutrophil apoptosis in infectious and inflammatory diseases is also addressed.

引用

页码：288 / 295

页数：8

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