Production of a novel viral suppressive activity associated with resistance to infection among female sex workers exposed to HIV type 1

被引:28
作者
Butera, ST
Pisell, TL
Limpakarnjanarat, K
Young, NL
Hodge, TW
Mastro, TD
Folks, TM
机构
[1] CDCP, HIV AIDS & Retrovirol Branch, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
[2] HIV AIDS Collaborat, Nonthaburi 11000, Thailand
[3] CDCP, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STP & TB Prevent, Atlanta, GA 30333 USA
[4] Ctr Dis Control & Prevent, HIV Immunol & Diagnost Branch, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
关键词
D O I
10.1089/088922201750237004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To investigate mechanisms of natural resistance to human immunodeficiency virus type 1 (HIV-1), we obtained blood samples from eight women who remained HIV-1 negative after >3 years of high-risk sex work in Chiang Rai, Thailand. CD4(+) T lymphocytes from these highly exposed, persistently seronegative (HEPS) women were readily infectable in vitro with HIV-1 subtypes B and E, Autologous CD8(+) cell suppression of both HIV-1 subtypes was evident in HEPS infection cultures, but to an extent also observed in cultures from non-HIV-exposed individuals, Furthermore, production of beta -chemokines was not enhanced in HEPS cultures. However, HEPS cultures displayed significantly enhanced production of a soluble activity that suppressed postintegrated HIV-1 replication. This activity was the unique product of CD4(+) T cell and monocyte cocultures, Therefore, although HEPS individuals are apparently susceptible to infection, the production of a postintegrated HIV-1 suppressive activity during monocyte-T cell interactions might protect against the establishment of infection by limiting viral dissemination.
引用
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页码:735 / 744
页数:10
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